What Do We Know About Clonazolam?
Clonazolam, also known as clonazepam, is an anti-convulsive drug that belongs to the benzodiazepine class. The drug’s central benzene ring is essentially a typical benzodiazepine that attaches to a seven-member ring. The diazepine ring has two nitrogen groups at positions R1 and R4.
In clonazolam, instead of the benzyl ring on P8, there is an N02 (nitro group). The diazepam ring binds to the 2-chlorinated phenyl ring to R6, and the 1-methylated triazole ring connects with the diazepine ring. The fusion triazole ring is a characteristic class of benzodiazepine.
Researchers and scientists recently discovered clonazolam. This chemical compound consists of two chemical bases – diClonazepam (Klonopin, Rivotril) and alprazolam (Xanax). Also, the FDA has approved both clonazepam and alprazolam for usage.
The drug was developed for the first time in 1971 and was the most active substance in the series. Today it is easily accessible through online research chemical vendors. However, there is still not enough information about this drug. Some researches labeled the drug clonazolam. Clonazolam is very potent as a volumetric dosage solution or on a blotter-paper. So, when compared to other bendiazepams, taking clonazolam and flubromazolam is risky due to a sedative effect these can cause.
So clonazepam is a potent drug that shows its effect in quantities of micrograms. If the user doesn’t intake the drug properly, it can cause significant problems. Moreover, Clonazepam, as a drug that belongs to the benzodiazepine class, can cause addiction. For this reason, doctors recommend a gradual decrease in the daily dose.
How Does Our Body React to Clonazolam?
Clonazolam causes physical, cognitive, visual, and paradoxical effects.
Furthermore, clonazolam has the potential to be extremely sedating, which often results in an overwhelmingly lethargic state. Therefore, if people consume the drug in higher doses, they can experience a sudden feeling of sleepiness, as if they have not slept for days. This feeling of sleep deprivation forces them to sit down because they feel like they are on the verge of passing out all the time.
If they take higher doses, users will experience a stronger sense of sleep deprivation that ultimately becomes powerful enough to force them into complete unconsciousness.
Clonazepam induces anxiolytic, hypnotic, and amnesic effects which act as an anticonvulsant to people using this drug. In addition, it produces moderate to strong feelings of relaxation, pleasure, and body comfort. Also, existing symptoms of illness (if they exist) will intensify after the admission of this drug.
Clonazepam, like benzodiazepam, causes receptor sites to bind to benzodiazepines. This newly-formed bond enhances the effects of GABA — a neurotransmitter. The consequence is the inhibitory effect and sedation of the person taking this drug.
Clonazepam acts as an anticonvulsant by completely or partially attaching to voltage-dependent Na channels, even more so than the ones associated with benzodyserme receptors.
Thiosemicarbazide and pentobarbital can cause the convulsions. Clonazepam antagonizes that effect.
What Physical Changes Does Clonazolam Cause?
Clonazolam has multiple effects on the nervous system — it causes sedation, dizziness, etc. Also, it decreases the severity and the frequency of seizures. Besides the nervous system, it can cause respiratory depression, loss of motor control, muscle relaxation, and increased libido.
In less than 1% of people, the drug will affect the nervous system by causing symptoms such as anxiety, irritability, aggressive behaviour, and violent and suicidal ideas. Such effects are more heightened when the user takes higher doses of the drug. Also, patients with mental disorders are more sensitive to these effects.
The drug can cause cognitive disorders, amnesia, as well as difficulty in the thinking process and information processing. Furthermore, it can cause impulsivity, reduced consciousness, and misconceptions about sobriety.
The side effects of taking this medicine can also cause repeated anxiety, persistent drowsiness, altered mental activity, disorientation, and lack of motivation.
Discontinuation of the drug should be gradual — users should reduce the dose slowly over an extended period of time.
Clonazolam, like benzodazepine, causes addiction.
When to Avoid Taking Clonazolam
You should not take clonazolam if you have glaucoma, severe liver disease, or a history of allergic reactions to any benzodiazepine.
To be sure that the medicine is safe to use, you must inform your doctor if you have ever had a history of kidney or liver disease, glaucoma, porphyria, asthma, emphysema, and bronchitis. Also, patients with chronic obstructive pulmonary disorder (COPD) or other breathing problems should avoid taking this drug.
In addition, if you suffer from depression or you have suicidal thoughts, you should be extra cautious when taking this drug. Also, avoid using this drug if you suffer from a mental illness, psychosis, an addiction to drugs or alcohol, or if you are using a narcotic (opioid) medication.
Possible Dangerous Interactions With Other Substances
If used individually, many psychoactive substances are safe. However, if users combine them with other drugs and substances, their effect can be very dangerous. Moreover, patients who use higher dosages face greater risks of experiencing some of the side effects the drug causes.
If a user takes clonazolam together with depressants (2M2B, alcohol, 1,4-butanediol, barbiturates, GHB/GBL, benzodiazepines, opioids, or methaqualone), he/she can experience stronger muscle relaxation, amnesia, sedation, and respiratory depression.
Also, if a patient takes a higher dose of clonazolam, sudden loss of consciousness, respiratory depression, nausea, or vomiting can occur. In that case, the best therapy is rest and sleep, possibly close to the place where the loss of consciousness occurred.
Taking clonazolam with other stimulants means facing a higher risk of poisoning. Stimulants mask the sedative effect of depressants. Therefore, once the effects of the stimulant wear off, the effects of the depressant will significantly increase. Then, loss of motor control may occur. Also, in order to avoid dehydration, patients must control their fluid intake regularly.
If a user intakes clonazolam and stimulants at the same time, he/she should strictly limit themselves to a pre-set dosing schedule. So, the user can consume only a certain amount per hour before he/she reaches the maximum threshold.
Finally, the combination with dissociatives is unpredictable. It can cause or potentiate amnesia, sedation, motor control loss, and delusions. Also, it can provoke a loss of consciousness accompanied by a dangerous degree of respiratory depression.
Clonazolam Dosage Info
Users primarily take Clonazolam orally. Its effects last for 6 to 10 hours. The first symptoms begin after 10-30 minutes.
Patients can consume the drug in a wide range of doses. The regular treatment is 50mg, the lower dose is 75mg, the common dose is 200mg to 400mg, the high dose is 400mg-1000mg, and a very high dose is about 1000mg.
If the patient takes excessive doses, he/she should go to the hospital immediately. The consequences of drug abuse can be very serious, especially if users fail to act accordingly. Some of the consequences include coma, brain damage, and death.
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